Protein profile

KP13_02227

Outer membrane usher protein fimD

Genome: KpKP13

Gene: AHE42797.1 fimD Structure source: AlphaFold + ColabFold UniProt A0A0H3GY15
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Amino acids 870
Annotations 5
Features 27
PDB binders 0
Druggability 0.349

Overview

Basic information about this protein and its source genome.

Accession
KP13_02227
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42797.1 fimD
Status
annotated
Amino acids
870
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
59.212
DEG E-value
0.0
Localization
OuterMembrane
ColabFold pLDDT
87.46

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.349
Structure A0A0H3GY15
Pocket Pocket 8
P2Rank 0.638
Structure A0A0H3GY15
Pocket Pocket 1
ColabFold model
FPocket 0.691 · Pocket 74
P2Rank 0.592 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 37 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005515 Binding to a protein.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
  • GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
1 37 Phobius SIGNAL_PEPTIDE Signal peptide region
40 184 Pfam PF13954 PapC N-terminal domain
40 184 InterPro IPR025885 PapC, N-terminal domain
697 787 Gene3D G3DSA:2.60.40.2610 Outer membrane usher protein FimD, plug domain
697 787 InterPro IPR042186 Outer membrane usher protein FimD, plug domain
18 869 PANTHER PTHR30451 OUTER MEMBRANE USHER PROTEIN
18 869 InterPro IPR000015 Outer membrane usher protein
38 870 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
788 870 FunFam G3DSA:2.60.40.2070:FF:000001 Fimbrial outer membrane usher protein
275 364 FunFam G3DSA:2.60.40.3110:FF:000001 Putative fimbrial outer membrane usher
317 327 ProSitePatterns PS01151 Fimbrial biogenesis outer membrane usher protein signature.
317 327 InterPro IPR018030 Fimbrial membrane usher, conserved site
30 37 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
788 870 Gene3D G3DSA:2.60.40.2070 -
788 870 InterPro IPR043142 PapC-like, C-terminal domain superfamily
200 782 Pfam PF00577 Outer membrane usher protein
200 782 InterPro IPR000015 Outer membrane usher protein
1 18 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
38 162 Gene3D G3DSA:3.10.20.410 -
38 162 InterPro IPR037224 PapC, N-terminal domain superfamily
697 787 FunFam G3DSA:2.60.40.2610:FF:000001 Outer membrane fimbrial usher protein
63 176 SUPERFAMILY SSF141729 FimD N-terminal domain-like
63 176 InterPro IPR037224 PapC, N-terminal domain superfamily
19 29 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
275 364 Gene3D G3DSA:2.60.40.3110 -
791 855 Pfam PF13953 PapC C-terminal domain
791 855 InterPro IPR025949 PapC-like, C-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GY15
AlphaFold — — full sequence — Viewing
ColabFold KP13_02227
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.349
73 0.303
67 0.204

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.79 0.347
2 4.56 0.196
3 2.04 0.045
4 1.73 0.031
5 1.42 0.018