Protein profile

KP13_02240

Outer membrane usher protein mrkC

Genome: KpKP13

Gene: mrkC AHE42813.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUY3
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Amino acids 828
Annotations 5
Features 27
PDB binders 0
Druggability 0.209

Overview

Basic information about this protein and its source genome.

Accession
KP13_02240
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
mrkC AHE42813.1
Status
annotated
Amino acids
828
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
84.18

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.209
Structure A0A0H3GUY3
Pocket Pocket 71
P2Rank 0.942
Structure A0A0H3GUY3
Pocket Pocket 1
ColabFold model
FPocket 0.171 · Pocket 17
P2Rank 0.881 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 18 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005515 Binding to a protein.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
  • GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
269 358 FunFam G3DSA:2.60.40.3110:FF:000001 Putative fimbrial outer membrane usher
269 358 Gene3D G3DSA:2.60.40.3110 -
37 181 Pfam PF13954 PapC N-terminal domain
37 181 InterPro IPR025885 PapC, N-terminal domain
198 751 Pfam PF00577 Outer membrane usher protein
198 751 InterPro IPR000015 Outer membrane usher protein
7 824 PANTHER PTHR30451 OUTER MEMBRANE USHER PROTEIN
7 824 InterPro IPR000015 Outer membrane usher protein
761 816 Pfam PF13953 PapC C-terminal domain
761 816 InterPro IPR025949 PapC-like, C-terminal domain
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
29 828 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
23 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
762 827 Gene3D G3DSA:2.60.40.2070 -
762 827 InterPro IPR043142 PapC-like, C-terminal domain superfamily
1 28 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
11 22 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 28 SignalP_EUK SignalP-noTM SignalP-noTM
60 172 SUPERFAMILY SSF141729 FimD N-terminal domain-like
60 172 InterPro IPR037224 PapC, N-terminal domain superfamily
51 169 Gene3D G3DSA:3.10.20.410 -
51 169 InterPro IPR037224 PapC, N-terminal domain superfamily
666 755 Gene3D G3DSA:2.60.40.2610 Outer membrane usher protein FimD, plug domain
666 755 InterPro IPR042186 Outer membrane usher protein FimD, plug domain
311 321 ProSitePatterns PS01151 Fimbrial biogenesis outer membrane usher protein signature.
311 321 InterPro IPR018030 Fimbrial membrane usher, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUY3
AlphaFold — — full sequence — Viewing
ColabFold KP13_02240
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
71 0.209

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.85 0.875
2 11.33 0.606
3 6.93 0.358
4 2.65 0.077
5 2.49 0.069