Protein profile

KP13_02241

Fimbria adhesin protein

Genome: KpKP13

Gene: AHE42814.1 mrkD Structure source: AlphaFold + ColabFold UniProt A0A0H3GX74
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Amino acids 331
Annotations 3
Features 16
PDB binders 0
Druggability 0.241

Overview

Basic information about this protein and its source genome.

Accession
KP13_02241
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42814.1 mrkD
Status
annotated
Amino acids
331
Structure source
AlphaFold + ColabFold
GO
GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Extracellular
ColabFold pLDDT
89.78

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.241
Structure A0A0H3GX74
Pocket Pocket 16
P2Rank 0.512
Structure A0A0H3GX74
Pocket Pocket 1
ColabFold model
FPocket 0.028 · Pocket 6
P2Rank 0.56 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher core
Gut microbiome 11 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
  • GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
  • GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 23 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
24 331 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 331 PANTHER PTHR33420 FIMBRIAL SUBUNIT ELFA-RELATED
182 330 Pfam PF00419 Fimbrial protein
182 330 InterPro IPR000259 Fimbrial-type adhesion domain
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
186 330 Gene3D G3DSA:2.60.40.1090 -
186 330 InterPro IPR036937 Fimbrial-type adhesion domain superfamily
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
17 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
6 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 25 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
186 331 SUPERFAMILY SSF49401 Bacterial adhesins
186 331 InterPro IPR008966 Adhesion domain superfamily
22 185 Gene3D G3DSA:2.60.40.3310 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GX74
AlphaFold — — full sequence — Viewing
ColabFold KP13_02241
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
16 0.241

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.96 0.48
2 2.8 0.086