Protein profile

KP13_02248

hypothetical protein

Genome: KpKP13

Gene: AHE42821.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSR7
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Amino acids 153
Annotations 0
Features 19
PDB binders 0
Druggability 0.959

Overview

Basic information about this protein and its source genome.

Accession
KP13_02248
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42821.1
Status
annotated
Amino acids
153
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
85.12

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.959
Structure A0A0H3GSR7
Pocket Pocket 4
P2Rank 0.548
Structure A0A0H3GSR7
Pocket Pocket 1
ColabFold model
FPocket 0.848 · Pocket 1
P2Rank 0.659 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 78 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
1 14 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
77 140 Pfam PF05232 Chlorhexidine efflux transporter
77 140 InterPro IPR007896 Chlorhexidine efflux transporter
9 71 Pfam PF05232 Chlorhexidine efflux transporter
9 71 InterPro IPR007896 Chlorhexidine efflux transporter
108 112 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
11 138 NCBIfam NF033664 PACE efflux transporter
86 107 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
86 108 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
10 139 NCBIfam NF033665 multidrug/biocide efflux PACE transporter
113 134 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
135 153 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
66 85 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
39 43 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
44 66 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
44 65 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
15 38 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
112 134 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSR7
AlphaFold — — full sequence — Viewing
ColabFold KP13_02248
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.959
3 0.409

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.75 0.524
2 1.53 0.023
3 0.58 0.0