Protein profile

KP13_02252

Oligogalacturonate lyase

Genome: KpKP13

Gene: AHE42825.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXZ1
Export view
Amino acids 391
Annotations 3
Features 5
PDB binders 0
Druggability 0.045

Overview

Basic information about this protein and its source genome.

Accession
KP13_02252
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42825.1
Status
annotated
Amino acids
391
Structure source
AlphaFold + ColabFold
GO
GO:0045490 The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. GO:0005515 Binding to a protein. GO:0047487 Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
42.308
DEG E-value
0.24
Localization
Unknown
ColabFold pLDDT
94.42

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.045
Structure A0A0H3GXZ1
Pocket Pocket 19
P2Rank 0.879
Structure A0A0H3GXZ1
Pocket Pocket 1
ColabFold model
FPocket 0.792 · Pocket 10
P2Rank 0.927 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 50 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0045490 The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.
  • GO:0005515 Binding to a protein.
  • GO:0047487 Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
1 384 Pfam PF14583 Oligogalacturonate lyase
1 384 InterPro IPR027946 Oligogalacturonate lyase domain
1 390 Gene3D G3DSA:2.130.10.10 -
1 390 InterPro IPR015943 WD40/YVTN repeat-like-containing domain superfamily
16 382 SUPERFAMILY SSF82171 DPP6 N-terminal domain-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXZ1
AlphaFold — — full sequence — Viewing
ColabFold KP13_02252
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.89 0.531
2 9.4 0.505
3 8.14 0.433
4 6.53 0.33
5 3.21 0.111