Protein profile

KP13_02258

Raffinose permease

Genome: KpKP13

Gene: AHE42830.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSQ6
Export view
Amino acids 413
Annotations 7
Features 69
PDB binders 0
Druggability 0.436

Overview

Basic information about this protein and its source genome.

Accession
KP13_02258
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42830.1
Status
annotated
Amino acids
413
Structure source
AlphaFold + ColabFold
GO
GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005351 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0030395 Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
42.818
DEG E-value
5.879999999999999e-94
Localization
CytoplasmicMembrane
ColabFold pLDDT
82.59

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.436
Structure A0A0H3GSQ6
Pocket Pocket 29
P2Rank 0.952
Structure A0A0H3GSQ6
Pocket Pocket 1
ColabFold model
FPocket 0.914 · Pocket 1
P2Rank 0.957 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 65 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005351 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in).
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0030395 Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk.
  • GO:0015528 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in).

Sequence Features

Domain/signature hits from InterPro and related databases.

69 records
Show feature table
Start End DB Term Name
344 365 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
146 164 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
25 32 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
286 305 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
377 396 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
45 67 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
8 400 SUPERFAMILY SSF103473 MFS general substrate transporter
8 400 InterPro IPR036259 MFS transporter superfamily
96 100 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
165 169 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
213 235 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
77 95 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
170 189 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
145 164 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
259 279 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
6 197 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
6 197 InterPro IPR036259 MFS transporter superfamily
280 285 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
377 396 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
168 187 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
103 125 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
306 310 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
333 343 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
76 98 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
9 396 NCBIfam TIGR00882 oligosaccharide MFS transporter
9 396 InterPro IPR000576 LacY/RafB permease family
210 235 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
280 306 PRINTS PR00174 LacY proton/sugar symporter family signature
280 306 InterPro IPR000576 LacY/RafB permease family
311 330 PRINTS PR00174 LacY proton/sugar symporter family signature
311 330 InterPro IPR000576 LacY/RafB permease family
103 125 PRINTS PR00174 LacY proton/sugar symporter family signature
103 125 InterPro IPR000576 LacY/RafB permease family
69 98 PRINTS PR00174 LacY proton/sugar symporter family signature
69 98 InterPro IPR000576 LacY/RafB permease family
256 277 PRINTS PR00174 LacY proton/sugar symporter family signature
256 277 InterPro IPR000576 LacY/RafB permease family
145 163 PRINTS PR00174 LacY proton/sugar symporter family signature
145 163 InterPro IPR000576 LacY/RafB permease family
211 239 PRINTS PR00174 LacY proton/sugar symporter family signature
211 239 InterPro IPR000576 LacY/RafB permease family
342 362 PRINTS PR00174 LacY proton/sugar symporter family signature
342 362 InterPro IPR000576 LacY/RafB permease family
366 376 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
33 47 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
397 413 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
257 279 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
203 407 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
203 407 InterPro IPR036259 MFS transporter superfamily
1 27 SignalP_EUK SignalP-TM SignalP-TM
9 400 Pfam PF01306 LacY proton/sugar symporter
9 400 InterPro IPR000576 LacY/RafB permease family
190 209 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
345 367 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
236 258 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
101 125 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
286 305 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
126 145 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 400 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
1 400 InterPro IPR020846 Major facilitator superfamily domain
310 332 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
311 332 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
48 67 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
68 76 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
2 400 PANTHER PTHR23522 BLL5896 PROTEIN
1 32 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSQ6
AlphaFold — — full sequence — Viewing
ColabFold KP13_02258
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
29 0.436
15 0.369
36 0.335
9 0.225

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.63 0.872
2 4.84 0.216
3 4.13 0.167
4 3.3 0.116
5 3.08 0.103