Protein profile

KP13_02260

glycoporin RfaY

Genome: KpKP13

Gene: AHE42832.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUW9
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Amino acids 447
Annotations 0
Features 12
PDB binders 0
Druggability 0.968

Overview

Basic information about this protein and its source genome.

Accession
KP13_02260
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42832.1
Status
annotated
Amino acids
447
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
58.52
DEG E-value
0.0
Localization
OuterMembrane
ColabFold pLDDT
78.92

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.968
Structure A0A0H3GUW9
Pocket Pocket 12
P2Rank 0.581
Structure A0A0H3GUW9
Pocket Pocket 1
ColabFold model
FPocket 0.904 · Pocket 34
P2Rank 0.865 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 65 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
83 447 Pfam PF16966 Porin-like glycoporin RafY
83 447 InterPro IPR016963 Glycoporin RafY
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 20 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
78 444 SUPERFAMILY SSF56935 Porins
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
21 447 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
25 54 Pfam PF11471 Maltoporin periplasmic N-terminal extension
25 54 InterPro IPR021570 LamB-type porin N-terminal domain
30 57 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUW9
AlphaFold — — full sequence — Viewing
ColabFold KP13_02260
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.968

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.4 0.323
2 5.97 0.293
3 3.82 0.148
4 2.82 0.088
5 2.59 0.074