Protein profile

KP13_02272

Uxu operon regulator

Genome: KpKP13

Gene: uxuR AHE42844.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXX1
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Amino acids 257
Annotations 3
Features 26
PDB binders 1
Druggability 0.187

Overview

Basic information about this protein and its source genome.

Accession
KP13_02272
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
uxuR AHE42844.1
Status
annotated
Amino acids
257
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
84.25

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.187
Structure A0A0H3GXX1
Pocket Pocket 12
P2Rank 0.872
Structure A0A0H3GXX1
Pocket Pocket 1
ColabFold model
FPocket 0.608 · Pocket 11
P2Rank 0.871 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 49 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
10 78 ProSiteProfiles PS50949 GntR-type HTH domain profile.
10 78 InterPro IPR000524 Transcription regulator HTH, GntR
13 75 CDD cd07377 WHTH_GntR
13 75 InterPro IPR000524 Transcription regulator HTH, GntR
10 79 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
10 79 InterPro IPR036390 Winged helix DNA-binding domain superfamily
116 136 Coils Coil Coil
6 79 Gene3D G3DSA:1.10.10.10 -
6 79 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
10 232 PANTHER PTHR43537 TRANSCRIPTIONAL REGULATOR, GNTR FAMILY
98 224 Pfam PF07729 FCD domain
98 224 InterPro IPR011711 GntR, C-terminal
98 225 SMART SM00895 FCD_2
98 225 InterPro IPR011711 GntR, C-terminal
97 233 SUPERFAMILY SSF48008 GntR ligand-binding domain-like
97 233 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
97 234 Gene3D G3DSA:1.20.120.530 -
97 234 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
35 49 PRINTS PR00035 GntR bacterial regulatory protein HTH signature
35 49 InterPro IPR000524 Transcription regulator HTH, GntR
49 65 PRINTS PR00035 GntR bacterial regulatory protein HTH signature
49 65 InterPro IPR000524 Transcription regulator HTH, GntR
12 75 Pfam PF00392 Bacterial regulatory proteins, gntR family
12 75 InterPro IPR000524 Transcription regulator HTH, GntR
16 75 SMART SM00345 gntr3
16 75 InterPro IPR000524 Transcription regulator HTH, GntR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXX1
AlphaFold — — full sequence — Viewing
ColabFold KP13_02272
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.16 0.866

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
3VV
4PDK
Q9KQU8 1032.0 Da LogP 4.70 TPSA 363.6 3 viol. ✓ Clean CCCCCCCC/C=C\CCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@@H…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.