Protein profile

KP13_02281

DNA mismatch repair protein mutH

Genome: KpKP13

Gene: mutH AHE42853.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GX33
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Amino acids 231
Annotations 6
Features 14
PDB binders 0
Druggability 0.313

Overview

Basic information about this protein and its source genome.

Accession
KP13_02281
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
mutH AHE42853.1
Status
annotated
Amino acids
231
Structure source
AlphaFold + ColabFold
GO
GO:0006304 The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0006298 A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.95

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.313
Structure A0A0H3GX33
Pocket Pocket 2
P2Rank 0.565
Structure A0A0H3GX33
Pocket Pocket 1
ColabFold model
FPocket 0.508 · Pocket 5
P2Rank 0.698 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 141 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0006304 The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0006298 A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 229 Gene3D G3DSA:3.40.600.10 DNA mismatch repair MutH/Restriction endonuclease, type II
1 229 InterPro IPR037057 DNA mismatch repair MutH/Type II restriction endonuclease superfamily
1 229 FunFam G3DSA:3.40.600.10:FF:000001 DNA mismatch repair protein MutH
1 231 Hamap MF_00759 DNA mismatch repair protein MutH [mutH].
1 231 InterPro IPR004230 DNA mismatch repair protein MutH
10 226 NCBIfam TIGR02248 DNA mismatch repair endonuclease MutH
10 226 InterPro IPR004230 DNA mismatch repair protein MutH
59 157 SMART SM00927 MutH_2
59 157 InterPro IPR011337 DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
18 225 CDD cd00583 MutH-like
18 225 InterPro IPR011337 DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
8 227 SUPERFAMILY SSF52980 Restriction endonuclease-like
8 227 InterPro IPR011335 Restriction endonuclease type II-like
59 157 Pfam PF02976 DNA mismatch repair enzyme MutH

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GX33
AlphaFold — — full sequence — Viewing
ColabFold KP13_02281
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.313
10 0.255

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.32 0.318
2 3.8 0.147
3 2.04 0.045