Protein profile

KP13_15241

Prepilin peptidase-dependent protein B

Genome: KpKP13

Gene: ANJ86581.1 ppdB Structure source: AlphaFold + ColabFold UniProt A0A0H3GSM5

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Amino acids 187

Annotations 2

Features 12

PDB binders 0

Druggability 0.144

Overview

Basic information about this protein and its source genome.

Accession: KP13_15241
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: ANJ86581.1 ppdB
Status: annotated
Amino acids: 187
Structure source: AlphaFold + ColabFold

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 0.0
Localization: Unknown
ColabFold pLDDT: 93.82

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.144

Structure A0A0H3GSM5

Pocket Pocket 1

P2Rank

Structure A0A0H3GSM5

Pocket No pockets

ColabFold model

FPocket 0.019 · Pocket 7

P2Rank 0.068 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 58 / 4744 genomes with a hit

Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
32	187	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1	187	PIRSF	PIRSF004525	Pilin_peptidase-dep_B
1	187	InterPro	IPR016419	Prepilin peptidase-dependent protein B, predicted
10	32	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
4	27	Pfam	PF07963	Prokaryotic N-terminal methylation motif
4	27	InterPro	IPR012902	Prokaryotic N-terminal methylation site
5	27	NCBIfam	TIGR02532	prepilin-type N-terminal cleavage/methylation domain
5	27	InterPro	IPR012902	Prokaryotic N-terminal methylation site
13	31	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	12	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	28	ProSiteProfiles	PS51257	Prokaryotic membrane lipoprotein lipid attachment site profile.
3	152	PANTHER	PTHR39583	TYPE II SECRETION SYSTEM PROTEIN J-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0H3GSM5 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GSM5	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_15241	ColabFold	—	—	full sequence	—	Loaded