Protein profile

KP13_02290

hypothetical protein

Genome: KpKP13

Gene: AHE42861.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUU4
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Amino acids 107
Annotations 1
Features 10
PDB binders 0
Druggability 0.166

Overview

Basic information about this protein and its source genome.

Accession
KP13_02290
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42861.1
Status
annotated
Amino acids
107
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
68.76

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.166
Structure A0A0H3GUU4
Pocket Pocket 4
P2Rank
Structure A0A0H3GUU4
Pocket No pockets
ColabFold model
FPocket 0.547 · Pocket 1
P2Rank 0.033 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 42 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
9 29 ProSitePatterns PS00409 Prokaryotic N-terminal methylation site.
9 29 InterPro IPR012902 Prokaryotic N-terminal methylation site
34 107 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
33 104 Pfam PF12528 Type II secretion prepilin peptidase dependent protein C
33 104 InterPro IPR022204 Prepilin peptidase dependent protein C-like, C-terminal domain
8 29 NCBIfam TIGR02532 prepilin-type N-terminal cleavage/methylation domain
8 29 InterPro IPR012902 Prokaryotic N-terminal methylation site
10 32 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 33 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUU4
AlphaFold — — full sequence — Viewing
ColabFold KP13_02290
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer