Protein profile

KP13_02301

Propanediol utilization protein pduV

Genome: KpKP13

Gene: pduV AHE42872.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GX16
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Amino acids 146
Annotations 2
Features 12
PDB binders 0
Druggability 0.636

Overview

Basic information about this protein and its source genome.

Accession
KP13_02301
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
pduV AHE42872.1
Status
annotated
Amino acids
146
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006576 The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.81

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.636
Structure A0A0H3GX16
Pocket Pocket 6
P2Rank 0.188
Structure A0A0H3GX16
Pocket Pocket 1
ColabFold model
FPocket 0.495 · Pocket 5
P2Rank 0.225 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 45 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0006576 The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 141 Pfam PF10662 Ethanolamine utilisation - propanediol utilisation
1 141 InterPro IPR012381 Ethanolamine/propanediol utilisation protein, EutP/PduV
3 140 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
3 140 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
2 141 NCBIfam TIGR02528 EutP/PduV family microcompartment system protein
2 141 InterPro IPR012381 Ethanolamine/propanediol utilisation protein, EutP/PduV
1 146 PIRSF PIRSF036409 EutP_PduV
1 146 InterPro IPR012381 Ethanolamine/propanediol utilisation protein, EutP/PduV
1 143 Gene3D G3DSA:3.40.50.300 -
1 143 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 144 PANTHER PTHR40453 PROTEIN YOEF
1 144 InterPro IPR012381 Ethanolamine/propanediol utilisation protein, EutP/PduV

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GX16
AlphaFold — — full sequence — Viewing
ColabFold KP13_02301
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.636
1 0.222
2 0.097
7 0.003

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.03 0.188
2 3.61 0.108
3 1.65 0.023