Protein profile

KP13_02314

Diol dehydratase-reactivating factor alpha subunit

Genome: KpKP13

Gene: ddrA AHE42885.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H288
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Amino acids 610
Annotations 2
Features 21
PDB binders 0
Druggability 0.638

Overview

Basic information about this protein and its source genome.

Accession
KP13_02314
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ddrA AHE42885.1
Status
annotated
Amino acids
610
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.0

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.638
Structure A0A0H3H288
Pocket Pocket 2
P2Rank 0.975
Structure A0A0H3H288
Pocket Pocket 1
ColabFold model
FPocket 0.725 · Pocket 2
P2Rank 0.982 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 170 / 4744 genomes with a hit
Normalized 0.036

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
93 254 Pfam PF18427 DD-reactivating factor swiveling domain
93 254 InterPro IPR040916 DD-reactivating factor swiveling domain
407 600 SUPERFAMILY SSF53067 Actin-like ATPase domain
407 600 InterPro IPR043129 ATPase, nucleotide binding domain
251 403 SUPERFAMILY SSF53067 Actin-like ATPase domain
251 403 InterPro IPR043129 ATPase, nucleotide binding domain
1 608 PIRSF PIRSF011502 DdrA_PduG
1 608 InterPro IPR009191 Diol dehydratase-reactivating factor large subunit
97 247 Gene3D G3DSA:3.50.30.70 Swiveling domain of dehydratase reactivase alpha subunit
97 247 InterPro IPR028975 Diol dehydratase-reactivating factor, alpha subunit, swiveling domain superfamily
2 601 Gene3D G3DSA:3.30.420.40 -
405 581 Gene3D G3DSA:3.30.420.40 -
93 254 SUPERFAMILY SSF82317 Swiveling domain of dehydratase reactivase alpha subunit
93 254 InterPro IPR028975 Diol dehydratase-reactivating factor, alpha subunit, swiveling domain superfamily
77 370 Gene3D G3DSA:3.90.470.30 -
275 602 Pfam PF08841 Diol dehydratase reactivase ATPase-like domain
275 602 InterPro IPR030994 Diol dehydratase reactivase ATPase-like domain
3 601 NCBIfam TIGR04491 diol dehydratase reactivase subunit alpha
3 601 InterPro IPR009191 Diol dehydratase-reactivating factor large subunit
466 510 Gene3D G3DSA:2.40.50.140 -
466 510 InterPro IPR012340 Nucleic acid-binding, OB-fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H288
AlphaFold — — full sequence — Viewing
ColabFold KP13_02314
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.638
1 0.002
17 0.001
3 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 55.88 0.975
2 3.17 0.086
3 2.41 0.053
4 1.57 0.02