Protein profile

KP13_02315

Propanediol dehydratase small subunit

Genome: KpKP13

Gene: pduE AHE42886.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUP1
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Amino acids 174
Annotations 0
Features 8
PDB binders 0
Druggability 0.604

Overview

Basic information about this protein and its source genome.

Accession
KP13_02315
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
pduE AHE42886.1
Status
annotated
Amino acids
174
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.11

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.604
Structure A0A0H3GUP1
Pocket Pocket 11
P2Rank 0.22
Structure A0A0H3GUP1
Pocket Pocket 1
ColabFold model
FPocket 0.451 · Pocket 5
P2Rank 0.273 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 75 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
82 174 Gene3D G3DSA:1.10.1510.20 Propanediol/glycerol dehydratase, small subunit
82 174 InterPro IPR036091 Propanediol/glycerol dehydratase, small subunit superfamily
41 171 Pfam PF02287 Dehydratase small subunit
41 171 InterPro IPR003207 Propanediol/glycerol dehydratase, small subunit
40 174 SUPERFAMILY SSF47148 Diol dehydratase, gamma subunit
40 174 InterPro IPR036091 Propanediol/glycerol dehydratase, small subunit superfamily
1 174 PIRSF PIRSF018505 Prpndl_dhdrts_sm
1 174 InterPro IPR003207 Propanediol/glycerol dehydratase, small subunit

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUP1
AlphaFold — — full sequence — Viewing
ColabFold KP13_02315
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.604
14 0.31
15 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.55 0.22
2 1.36 0.013