Protein profile

KP13_02331

Protein cbiG

Genome: KpKP13

Gene: AHE42901.1 cbiG Structure source: AlphaFold + ColabFold UniProt A0A0H3GSI1
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Amino acids 351
Annotations 1
Features 14
PDB binders 0
Druggability 0.926

Overview

Basic information about this protein and its source genome.

Accession
KP13_02331
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42901.1 cbiG
Status
annotated
Amino acids
351
Structure source
AlphaFold + ColabFold
GO
GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.08

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.926
Structure A0A0H3GSI1
Pocket Pocket 2
P2Rank 0.518
Structure A0A0H3GSI1
Pocket Pocket 1
ColabFold model
FPocket 0.8 · Pocket 1
P2Rank 0.461 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 45 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
2 129 Gene3D G3DSA:3.40.50.11220 -
5 350 PANTHER PTHR37477 COBALT-PRECORRIN-5A HYDROLASE
6 238 SUPERFAMILY SSF159672 CbiG N-terminal domain-like
6 238 InterPro IPR038029 GbiG N-terminal domain superfamily
140 217 Pfam PF11761 Cobalamin biosynthesis central region
140 217 InterPro IPR021745 Cobalamin biosynthesis central region
55 134 Pfam PF11760 Cobalamin synthesis G N-terminal
55 134 InterPro IPR021744 Cobalamin synthesis G, N-terminal
224 349 SUPERFAMILY SSF159664 CobE/GbiG C-terminal domain-like
224 349 InterPro IPR036518 CobE/GbiG C-terminal domain superfamily
222 350 Gene3D G3DSA:3.30.420.180 -
222 350 InterPro IPR036518 CobE/GbiG C-terminal domain superfamily
231 346 Pfam PF01890 Cobalamin synthesis G C-terminus
231 346 InterPro IPR002750 CobE/GbiG C-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSI1
AlphaFold — — full sequence — Viewing
ColabFold KP13_02331
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.926
1 0.35

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.68 0.275
2 4.62 0.2
3 4.15 0.168
4 1.03 0.006