Protein profile

KP13_02335

Cobalt-precorrin-2 C(20)-methyltransferase

Genome: KpKP13

Gene: AHE42905.1 cbiL Structure source: AlphaFold + ColabFold UniProt A0A0H3GXL1
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Amino acids 236
Annotations 5
Features 19
PDB binders 0
Druggability 0.742

Overview

Basic information about this protein and its source genome.

Accession
KP13_02335
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42905.1 cbiL
Status
annotated
Amino acids
236
Structure source
AlphaFold + ColabFold
GO
GO:0030788 Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H+ + precorrin-3A. GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.46

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.742
Structure A0A0H3GXL1
Pocket Pocket 1
P2Rank 0.79
Structure A0A0H3GXL1
Pocket Pocket 1
ColabFold model
FPocket 0.477 · Pocket 4
P2Rank 0.77 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 46 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0030788 Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H+ + precorrin-3A.
  • GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
  • GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
1 234 PANTHER PTHR43467 COBALT-PRECORRIN-2 C(20)-METHYLTRANSFERASE
94 126 ProSitePatterns PS00840 Uroporphyrin-III C-methyltransferase signature 2.
94 126 InterPro IPR003043 Uroporphiryn-III C-methyltransferase, conserved site
4 210 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases
4 210 InterPro IPR000878 Tetrapyrrole methylase
1 128 Gene3D G3DSA:3.40.1010.10 -
1 128 InterPro IPR014777 Tetrapyrrole methylase, subdomain 1
1 234 SUPERFAMILY SSF53790 Tetrapyrrole methylase
1 234 InterPro IPR035996 Tetrapyrrole methylase superfamily
1 236 PIRSF PIRSF036427 Precrrn-2_mtase
1 236 InterPro IPR012382 Precorrin-2 C(20)-methyltransferase
11 229 CDD cd11645 Precorrin_2_C20_MT
11 229 InterPro IPR012382 Precorrin-2 C(20)-methyltransferase
129 236 Gene3D G3DSA:3.30.950.10 -
129 236 InterPro IPR014776 Tetrapyrrole methylase, subdomain 2
3 231 NCBIfam TIGR01467 precorrin-2 C(20)-methyltransferase
3 231 InterPro IPR006364 Precorrin-2 C(20)-methyltransferase domain
8 22 ProSitePatterns PS00839 Uroporphyrin-III C-methyltransferase signature 1.
8 22 InterPro IPR003043 Uroporphiryn-III C-methyltransferase, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXL1
AlphaFold — — full sequence — Viewing
ColabFold KP13_02335
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.742

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.09 0.638
2 2.05 0.045