Protein profile

KP13_02338

Cobalt transport protein CbiQ

Genome: KpKP13

Gene: cbiQ AHE42908.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUL9
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Amino acids 225
Annotations 3
Features 27
PDB binders 0
Druggability 0.409

Overview

Basic information about this protein and its source genome.

Accession
KP13_02338
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
cbiQ AHE42908.1
Status
annotated
Amino acids
225
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006824 The directed movement of cobalt (Co2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0043190 A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.87

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.409
Structure A0A0H3GUL9
Pocket Pocket 7
P2Rank 0.03
Structure A0A0H3GUL9
Pocket Pocket 1
ColabFold model
FPocket 0.646 · Pocket 18
P2Rank 0.056 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 47 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0006824 The directed movement of cobalt (Co2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0043190 A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
85 90 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
136 155 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
92 110 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
65 84 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 21 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
16 216 NCBIfam TIGR02454 cobalt ECF transporter T component CbiQ
16 216 InterPro IPR012809 Cobalt ECF transporter T component CbiQ
63 85 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
10 221 Pfam PF02361 Cobalt transport protein
10 221 InterPro IPR003339 ABC/ECF transporter, transmembrane component
116 135 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
111 115 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
156 175 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
91 110 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
187 205 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
42 64 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
22 33 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
3 225 PANTHER PTHR43723 COBALT TRANSPORT PROTEIN CBIQ
55 224 CDD cd16914 EcfT
34 41 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
187 205 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
176 186 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
120 142 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
206 225 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 41 Phobius SIGNAL_PEPTIDE Signal peptide region
155 172 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUL9
AlphaFold — — full sequence — Viewing
ColabFold KP13_02338
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.409
15 0.27
1 0.241

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.3 0.058
2 1.68 0.029