Protein profile

KP13_02351

L-fucose operon activator

Genome: KpKP13

Gene: AHE42921.1 fucR Structure source: AlphaFold + ColabFold UniProt A0A0H3GSF9
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Amino acids 236
Annotations 3
Features 24
PDB binders 0
Druggability 0.441

Overview

Basic information about this protein and its source genome.

Accession
KP13_02351
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42921.1 fucR
Status
annotated
Amino acids
236
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.3

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.441
Structure A0A0H3GSF9
Pocket Pocket 3
P2Rank 0.665
Structure A0A0H3GSF9
Pocket Pocket 1
ColabFold model
FPocket 0.463 · Pocket 1
P2Rank 0.135 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 54 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
23 37 PRINTS PR00037 LacR bacterial regulatory protein HTH signature
23 37 InterPro IPR001034 DeoR-type HTH domain
37 55 PRINTS PR00037 LacR bacterial regulatory protein HTH signature
37 55 InterPro IPR001034 DeoR-type HTH domain
76 233 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
76 233 InterPro IPR037171 NagB/RpiA transferase-like
74 234 SMART SM01134 DeoRC_2
25 45 Coils Coil Coil
5 57 SMART SM00420 deor2
5 57 InterPro IPR001034 DeoR-type HTH domain
3 232 PANTHER PTHR30363 HTH-TYPE TRANSCRIPTIONAL REGULATOR SRLR-RELATED
5 60 Pfam PF08220 DeoR-like helix-turn-helix domain
5 60 InterPro IPR001034 DeoR-type HTH domain
76 232 Pfam PF00455 DeoR C terminal sensor domain
76 232 InterPro IPR014036 DeoR C-terminal sensor domain
75 231 Gene3D G3DSA:3.40.50.1360 -
2 57 ProSiteProfiles PS51000 DeoR-type HTH domain profile.
2 57 InterPro IPR001034 DeoR-type HTH domain
5 39 ProSitePatterns PS00894 DeoR-type HTH domain signature.
5 39 InterPro IPR018356 Transcription regulator, HTH DeoR-type, conserved site
1 54 Gene3D G3DSA:1.10.10.10 -
1 54 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
4 59 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
4 59 InterPro IPR036390 Winged helix DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSF9
AlphaFold — — full sequence — Viewing
ColabFold KP13_02351
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.441
9 0.4

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.01 0.539