Protein profile

KP13_02352

L-fucose mutarotase

Genome: KpKP13

Gene: AHE42922.1 fucU Structure source: AlphaFold + ColabFold UniProt A0A0H3H259
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Amino acids 140
Annotations 10
Features 10
PDB binders 0
Druggability 0.415

Overview

Basic information about this protein and its source genome.

Accession
KP13_02352
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42922.1 fucU
Status
annotated
Amino acids
140
Structure source
AlphaFold + ColabFold
EC
5.1.3.29
GO
GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0042354 The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants. GO:0016854 Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. GO:0005996 The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. GO:0048029 Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. GO:0042806 Binding to fucose, the pentose 6-deoxygalactose.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
47.222
Human E-value
2.05e-36
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
45.714
DEG E-value
1.36e-35
Localization
Cytoplasmic
ColabFold pLDDT
97.94

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.415
Structure A0A0H3H259
Pocket Pocket 2
P2Rank 0.053
Structure A0A0H3H259
Pocket Pocket 1
ColabFold model
FPocket 0.826 · Pocket 1
P2Rank 0.043 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 120 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 9 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

9
  • GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
  • GO:0042354 The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants.
  • GO:0016854 Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule.
  • GO:0005996 The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.
  • GO:0048029 Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.
  • GO:0042806 Binding to fucose, the pentose 6-deoxygalactose.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0062193 Catalysis of the reactions: beta-D-ribopyranose = beta-D-ribofuranose, and beta-allofuranose = beta-allopyranose.
  • GO:0036373 Catalysis of the reaction: alpha-L-fucose = beta-L-fucose.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 139 PANTHER PTHR31690 FUCOSE MUTAROTASE
1 140 FunFam G3DSA:3.40.1650.10:FF:000001 L-fucose mutarotase
3 139 Pfam PF05025 RbsD / FucU transport protein family
3 139 InterPro IPR007721 D-ribose pyranase RbsD/L-fucose mutarotase FucU
1 140 Hamap MF_01662 L-fucose mutarotase [fucU].
1 140 InterPro IPR023751 L-fucose mutarotase
1 140 Gene3D G3DSA:3.40.1650.10 -
1 140 InterPro IPR023750 RbsD-like superfamily
1 139 SUPERFAMILY SSF102546 RbsD-like
1 139 InterPro IPR023750 RbsD-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H259
AlphaFold — — full sequence — Viewing
ColabFold KP13_02352
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.415
6 0.41

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.33 0.015