Protein profile

KP13_02364

putative D-methionine transport system permease protein

Genome: KpKP13

Gene: AHE42935.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSE5
Export view
Amino acids 232
Annotations 4
Features 27
PDB binders 0
Druggability 0.805

Overview

Basic information about this protein and its source genome.

Accession
KP13_02364
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42935.1
Status
annotated
Amino acids
232
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0048473 The process in which D-methionine is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.47

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.805
Structure A0A0H3GSE5
Pocket Pocket 3
P2Rank 0.111
Structure A0A0H3GSE5
Pocket Pocket 1
ColabFold model
FPocket 0.851 · Pocket 2
P2Rank 0.124 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 13 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0048473 The process in which D-methionine is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
27 51 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
166 188 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
192 196 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 26 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
198 217 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
17 216 SUPERFAMILY SSF161098 MetI-like
17 216 InterPro IPR035906 MetI-like superfamily
217 232 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
14 226 Gene3D G3DSA:1.10.3720.10 -
14 226 InterPro IPR035906 MetI-like superfamily
92 96 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
170 191 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
197 216 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
97 115 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
52 71 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
56 225 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
56 225 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
70 92 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
17 226 PANTHER PTHR30450 ABC TRANSPORTER PERMEASE
27 49 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
23 217 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
23 217 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
72 91 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
116 169 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
26 213 CDD cd06261 TM_PBP2
26 213 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
96 118 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSE5
AlphaFold — — full sequence — Viewing
ColabFold KP13_02364
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.805
2 0.614

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.79 0.146
2 1.4 0.017
3 1.23 0.012