Protein profile

KP13_02368

Acyl-CoA dehydrogenase family protein

Genome: KpKP13

Gene: AHE42939.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWV9
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Amino acids 413
Annotations 4
Features 16
PDB binders 0
Druggability 0.83

Overview

Basic information about this protein and its source genome.

Accession
KP13_02368
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42939.1
Status
annotated
Amino acids
413
Structure source
AlphaFold + ColabFold
GO
GO:0016627 Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0050660 Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0008470 Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]. GO:0006552 The chemical reactions and pathways resulting in the breakdown of L-leucine.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
57.627
DEG E-value
2.88e-159
Localization
Unknown
ColabFold pLDDT
94.51

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.83
Structure A0A0H3GWV9
Pocket Pocket 4
P2Rank 0.949
Structure A0A0H3GWV9
Pocket Pocket 1
ColabFold model
FPocket 0.989 · Pocket 1
P2Rank 0.937 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 22 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016627 Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
  • GO:0050660 Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
  • GO:0008470 Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein].
  • GO:0006552 The chemical reactions and pathways resulting in the breakdown of L-leucine.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
3 89 PIRSF PIRSF016578 PIGM
136 399 PIRSF PIRSF016578 PIGM
224 404 Gene3D G3DSA:1.20.140.10 -
278 380 Pfam PF08028 Acyl-CoA dehydrogenase, C-terminal domain
278 380 InterPro IPR013107 Acyl-CoA dehydrogenase, C-terminal domain
126 223 Gene3D G3DSA:2.40.110.10 -
126 223 InterPro IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
28 123 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain
28 123 InterPro IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
238 381 SUPERFAMILY SSF47203 Acyl-CoA dehydrogenase C-terminal domain-like
238 381 InterPro IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
28 377 PANTHER PTHR43884 ACYL-COA DEHYDROGENASE
13 224 SUPERFAMILY SSF56645 Acyl-CoA dehydrogenase NM domain-like
13 224 InterPro IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
8 124 Gene3D G3DSA:1.10.540.10 -
8 124 InterPro IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWV9
AlphaFold — — full sequence — Viewing
ColabFold KP13_02368
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.83

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 27.75 0.922
2 3.17 0.108
3 2.16 0.051
4 2.11 0.048
5 2.06 0.046