Protein profile

KP13_02370

L-serine dehydratase 2

Genome: KpKP13

Gene: AHE42941.1 sdaB Structure source: AlphaFold + ColabFold UniProt A0A0H3GSE0
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Amino acids 455
Annotations 6
Features 12
PDB binders 0
Druggability 0.378

Overview

Basic information about this protein and its source genome.

Accession
KP13_02370
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42941.1 sdaB
Status
annotated
Amino acids
455
Structure source
AlphaFold + ColabFold
EC
4.3.1.17
GO
GO:0006094 The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003941 Catalysis of the reaction: L-serine = pyruvate + NH4+. GO:0046872 Binding to a metal ion. GO:0009063 The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
73.009
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.44

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.378
Structure A0A0H3GSE0
Pocket Pocket 8
P2Rank 0.3
Structure A0A0H3GSE0
Pocket Pocket 1
ColabFold model
FPocket 0.55 · Pocket 6
P2Rank 0.249 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 258 / 4744 genomes with a hit
Normalized 0.054

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0006094 The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0003941 Catalysis of the reaction: L-serine = pyruvate + NH4+.
  • GO:0046872 Binding to a metal ion.
  • GO:0009063 The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
16 158 SUPERFAMILY SSF143548 Serine metabolism enzymes domain
16 158 InterPro IPR029009 Allosteric substrate binding domain superfamily
10 159 Gene3D G3DSA:3.30.1330.90 -
10 159 InterPro IPR029009 Allosteric substrate binding domain superfamily
10 158 FunFam G3DSA:3.30.1330.90:FF:000001 L-serine ammonia-lyase 1
1 451 PANTHER PTHR30182 L-SERINE DEHYDRATASE
184 448 Pfam PF03313 Serine dehydratase alpha chain
184 448 InterPro IPR005130 Serine dehydratase-like, alpha subunit
2 451 NCBIfam TIGR00720 L-serine ammonia-lyase
2 451 InterPro IPR004644 Iron-sulphur-dependent L-serine dehydratase single chain form
3 155 Pfam PF03315 Serine dehydratase beta chain
3 155 InterPro IPR005131 Serine dehydratase beta chain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSE0
AlphaFold — — full sequence — Viewing
ColabFold KP13_02370
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.378
4 0.343
1 0.25

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.82 0.284
2 4.32 0.179
3 2.47 0.068
4 2.28 0.057
5 0.85 0.003