Protein profile

KP13_02387

Nucleoside triphosphate pyrophosphohydrolase

Genome: KpKP13

Gene: AHE42958.1 mazG Structure source: AlphaFold + ColabFold UniProt A0A0H3GSC4
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Amino acids 263
Annotations 9
Features 17
PDB binders 0
Druggability 0.925

Overview

Basic information about this protein and its source genome.

Accession
KP13_02387
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42958.1 mazG
Status
annotated
Amino acids
263
Structure source
AlphaFold + ColabFold
EC
3.6.1.8
GO
GO:0047693 Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate. GO:0046061 The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). GO:0006203 The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate. GO:0046076 The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate. GO:0046081 The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate. GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
49.807
DEG E-value
3.87e-95
Localization
Cytoplasmic
ColabFold pLDDT
92.4

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.925
Structure A0A0H3GSC4
Pocket Pocket 4
P2Rank 0.295
Structure A0A0H3GSC4
Pocket Pocket 1
ColabFold model
FPocket 0.626 · Pocket 9
P2Rank 0.29 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 154 / 4744 genomes with a hit
Normalized 0.032

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

8
  • GO:0047693 Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate.
  • GO:0046061 The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate).
  • GO:0006203 The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate.
  • GO:0046076 The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate.
  • GO:0046081 The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate.
  • GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
  • GO:0046047 The chemical reactions and pathways resulting in the breakdown of TTP, ribosylthymine triphosphate.
  • GO:0046052 The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
10 257 NCBIfam TIGR00444 MazG family protein
10 257 InterPro IPR011551 NTP pyrophosphohydrolase MazG
129 263 Gene3D G3DSA:1.10.287.1080 -
1 125 Gene3D G3DSA:1.10.287.1080 -
27 100 Pfam PF03819 MazG nucleotide pyrophosphohydrolase domain
27 100 InterPro IPR004518 NTP pyrophosphohydrolase MazG, putative catalytic core
168 227 Pfam PF03819 MazG nucleotide pyrophosphohydrolase domain
168 227 InterPro IPR004518 NTP pyrophosphohydrolase MazG, putative catalytic core
173 193 Coils Coil Coil
140 257 CDD cd11529 NTP-PPase_MazG_Cterm
129 261 FunFam G3DSA:1.10.287.1080:FF:000003 Nucleoside triphosphate pyrophosphohydrolase
1 124 FunFam G3DSA:1.10.287.1080:FF:000001 Nucleoside triphosphate pyrophosphohydrolase
135 236 SUPERFAMILY SSF101386 all-alpha NTP pyrophosphatases
2 261 PANTHER PTHR30522 NUCLEOSIDE TRIPHOSPHATE PYROPHOSPHOHYDROLASE
2 261 InterPro IPR011551 NTP pyrophosphohydrolase MazG
5 119 CDD cd11528 NTP-PPase_MazG_Nterm
2 105 SUPERFAMILY SSF101386 all-alpha NTP pyrophosphatases

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSC4
AlphaFold — — full sequence — Viewing
ColabFold KP13_02387
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.925
3 0.444

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.18 0.239
2 3.29 0.115
3 2.29 0.058