Protein profile

KP13_02399

Alkaline phosphatase isozyme conversion protein

Genome: KpKP13

Gene: iap AHE42970.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H216
Export view
Amino acids 348
Annotations 4
Features 14
PDB binders 0
Druggability 0.369

Overview

Basic information about this protein and its source genome.

Accession
KP13_02399
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
iap AHE42970.1
Status
annotated
Amino acids
348
Structure source
AlphaFold + ColabFold
GO
GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008235 Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0004177 Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
92.97

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.369
Structure A0A0H3H216
Pocket Pocket 16
P2Rank 0.826
Structure A0A0H3H216
Pocket Pocket 1
ColabFold model
FPocket 0.696 · Pocket 12
P2Rank 0.869 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 81 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
  • GO:0008235 Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
  • GO:0004177 Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
9 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
100 325 Pfam PF04389 Peptidase family M28
100 325 InterPro IPR007484 Peptidase M28
37 292 PANTHER PTHR12147 METALLOPEPTIDASE M28 FAMILY MEMBER
37 292 InterPro IPR045175 Peptidase M28 family
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
27 347 Gene3D G3DSA:3.40.630.10 Zn peptidases
21 27 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
28 348 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
30 348 FunFam G3DSA:3.40.630.10:FF:000038 Alkaline phosphatase isozyme conversion
41 315 SUPERFAMILY SSF53187 Zn-dependent exopeptidases
1 27 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H216
AlphaFold — — full sequence — Viewing
ColabFold KP13_02399
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
16 0.369

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.08 0.744
2 2.27 0.056
3 1.26 0.013