Protein profile

KP13_02513

Cell division ftsB-like protein

Genome: KpKP13

Gene: ftsB AHE42979.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUF5
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Amino acids 105
Annotations 4
Features 16
PDB binders 0
Druggability 0.529

Overview

Basic information about this protein and its source genome.

Accession
KP13_02513
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ftsB AHE42979.1
Status
annotated
Amino acids
105
Structure source
AlphaFold + ColabFold
GO
GO:0032153 The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0030428 A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0043093 A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
91.429
DEG E-value
1.7e-57
Localization
CytoplasmicMembrane
ColabFold pLDDT
83.47

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.529
Structure A0A0H3GUF5
Pocket Pocket 1
P2Rank
Structure A0A0H3GUF5
Pocket No pockets
ColabFold model
FPocket 0.507 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 126 / 4744 genomes with a hit
Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0032153 The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
  • GO:0030428 A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0043093 A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
15 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
4 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 20 SignalP_EUK SignalP-noTM SignalP-noTM
22 63 Gene3D G3DSA:1.20.5.400 -
11 89 Pfam PF04977 Septum formation initiator
11 89 InterPro IPR007060 Septum formation initiator FtsL/DivIC
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
86 105 MobiDBLite mobidb-lite consensus disorder prediction
1 93 PANTHER PTHR37485 CELL DIVISION PROTEIN FTSB
1 93 InterPro IPR023081 Cell division protein FtsB
1 90 Hamap MF_00599 Cell division protein FtsB [ftsB].
1 90 InterPro IPR023081 Cell division protein FtsB
19 105 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
22 63 FunFam G3DSA:1.20.5.400:FF:000001 Cell division protein FtsB
4 21 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUF5
AlphaFold — — full sequence — Viewing
ColabFold KP13_02513
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.529
6 0.154
3 0.0
5 0.0