Protein profile

KP13_02526

Phenolic acid decarboxylase subunit B

Genome: KpKP13

Gene: AHE42990.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXF7
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Amino acids 197
Annotations 5
Features 21
PDB binders 8
Druggability 0.547

Overview

Basic information about this protein and its source genome.

Accession
KP13_02526
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42990.1
Status
annotated
Amino acids
197
Structure source
AlphaFold + ColabFold
EC
2.5.1.129
GO
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016831 Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0106141 Catalysis of the reaction: dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2. GO:0009636 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
52.688
DEG E-value
3.8100000000000003e-66
Localization
Cytoplasmic
ColabFold pLDDT
95.66

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.547
Structure A0A0H3GXF7
Pocket Pocket 15
P2Rank 0.165
Structure A0A0H3GXF7
Pocket Pocket 1
ColabFold model
FPocket 0.374 · Pocket 3
P2Rank 0.414 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 187 / 4744 genomes with a hit
Normalized 0.039

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0016831 Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
  • GO:0106141 Catalysis of the reaction: dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2.
  • GO:0009636 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
9 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 185 Hamap MF_01984 Flavin prenyltransferase UbiX [ubiX].
1 185 InterPro IPR004507 Flavin prenyltransferase UbiX-like
25 197 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 186 FunFam G3DSA:3.40.50.1950:FF:000001 Flavin prenyltransferase UbiX
2 185 NCBIfam NF041206 non-oxidative hydroxyarylic acid decarboxylases subunit B
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
2 183 NCBIfam TIGR00421 UbiX family flavin prenyltransferase
2 183 InterPro IPR004507 Flavin prenyltransferase UbiX-like
1 185 SUPERFAMILY SSF52507 Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
1 185 InterPro IPR036551 Flavin prenyltransferase-like
1 197 Gene3D G3DSA:3.40.50.1950 -
1 197 InterPro IPR036551 Flavin prenyltransferase-like
21 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 164 Pfam PF02441 Flavoprotein
1 164 InterPro IPR003382 Flavoprotein
65 149 PANTHER PTHR43374 FLAVIN PRENYLTRANSFERASE
65 149 InterPro IPR004507 Flavin prenyltransferase UbiX-like
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
1 189 Hamap MF_01986 Probable UbiX-like flavin prenyltransferase.
1 189 InterPro IPR032901 Probable UbiX-like flavin prenyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXF7
AlphaFold — — full sequence — Viewing
ColabFold KP13_02526
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
15 0.547
5 0.454

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.29 0.058

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

33 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
4LR
6QLI
A0A072ZCW8 166.1 Da LogP 1.06 TPSA 66.8 ✓ Ro5 ✓ Clean CC(=CCOP(=O)(O)O)C
4LS
6QLJ
A0A072ZCW8 526.5 Da LogP 0.43 TPSA 199.6 2 viol. ✓ Clean Cc1cc2c(cc1C)N(C3=C(N2CC=C(C)C)C(=O)NC(=O)N3)C[…
4LU
6QLK
A0A072ZCW8 525.5 Da LogP -0.09 TPSA 199.4 2 viol. ✓ Clean Cc1cc2c3c(c1C)C(CC=[N+]3C4=C(N2C[C@@H]([C@@H]([…
DMA
6QLG
A3F715 246.1 Da LogP 1.18 TPSA 113.3 ✓ Ro5 ✓ Clean CC(=CCO[P@@](=O)(O)OP(=O)(O)O)C
FNR
6QLH
A0A072ZCW8 458.4 Da LogP -0.93 TPSA 208.4 1 viol. ✓ Clean Cc1cc2c(cc1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C…
HJN
6QLV
A0A072ZCW8 594.6 Da LogP 2.15 TPSA 199.6 2 viol. ✓ Clean Cc1cc2c(cc1C)N(C3=C(N2C/C=C(/C)\CCC=C(C)C)C(=O)…
HZZ
6QLV
A0A072ZCW8 234.2 Da LogP 2.79 TPSA 66.8 ✓ Ro5 ✓ Clean CC(=CCC/C(=C\COP(=O)(O)O)/C)C
IP8
6QLH
A0A072ZCW8 166.1 Da LogP 1.06 TPSA 66.8 ✓ Ro5 ✓ Clean CC(=C)CCOP(=O)(O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.