Protein profile

KP13_16268

putative phage integrase

Genome: KpKP13

Gene: ANJ86583.1 Structure source: AlphaFold + ColabFold UniProt A0A377WQG8
Export view
Amino acids 427
Annotations 3
Features 17
PDB binders 0
Druggability 0.64

Overview

Basic information about this protein and its source genome.

Accession
KP13_16268
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ANJ86583.1
Status
annotated
Amino acids
427
Structure source
AlphaFold + ColabFold
GO
GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.08

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.64
Structure A0A377WQG8
Pocket Pocket 4
P2Rank 0.291
Structure A0A377WQG8
Pocket Pocket 1
ColabFold model
FPocket 0.652 · Pocket 9
P2Rank 0.153 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 6 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
142 414 SUPERFAMILY SSF56349 DNA breaking-rejoining enzymes
142 414 InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core
97 117 Coils Coil Coil
237 413 Gene3D G3DSA:1.10.443.10 Intergrase catalytic core
237 413 InterPro IPR013762 Integrase-like, catalytic domain superfamily
9 426 PANTHER PTHR30629 PROPHAGE INTEGRASE
242 400 Pfam PF00589 Phage integrase family
242 400 InterPro IPR002104 Integrase, catalytic domain
244 422 CDD cd00801 INT_P4_C
238 419 ProSiteProfiles PS51898 Tyrosine recombinase domain profile.
238 419 InterPro IPR002104 Integrase, catalytic domain
9 111 Gene3D G3DSA:3.30.160.390 -
9 111 InterPro IPR038488 Integrase, DNA-binding domain superfamily
112 226 Gene3D G3DSA:1.10.150.130 -
112 226 InterPro IPR010998 Integrase/recombinase, N-terminal
16 97 Pfam PF13356 Arm DNA-binding domain
16 97 InterPro IPR025166 Integrase, DNA-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A377WQG8
AlphaFold — — full sequence — Viewing
ColabFold KP13_16268
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.64
14 0.382
1 0.359

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.48 0.127
2 2.53 0.071