Protein profile

KP13_02534

putative transposase

Genome: KpKP13

Gene: AHE42997.1 Structure source: AlphaFold + ColabFold UniProt A0A377VVV9
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Amino acids 270
Annotations 2
Features 14
PDB binders 0
Druggability 0.416

Overview

Basic information about this protein and its source genome.

Accession
KP13_02534
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42997.1
Status
annotated
Amino acids
270
Structure source
AlphaFold + ColabFold
GO
GO:0003676 Binding to a nucleic acid. GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
89.79

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.416
Structure A0A377VVV9
Pocket Pocket 1
P2Rank 0.296
Structure A0A377VVV9
Pocket Pocket 1
ColabFold model
FPocket 0.337 · Pocket 1
P2Rank 0.264 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 35 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003676 Binding to a nucleic acid.
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
2 264 PANTHER PTHR46889 TRANSPOSASE INSF FOR INSERTION SEQUENCE IS3B-RELATED
208 262 Pfam PF13333 Integrase core domain
208 262 InterPro IPR001584 Integrase, catalytic core
2 260 NCBIfam NF033516 IS3 family transposase
104 201 Pfam PF00665 Integrase core domain
104 201 InterPro IPR001584 Integrase, catalytic core
100 264 Gene3D G3DSA:3.30.420.10 -
100 264 InterPro IPR036397 Ribonuclease H superfamily
24 76 Pfam PF13276 HTH-like domain
24 76 InterPro IPR025948 HTH-like domain
101 264 ProSiteProfiles PS50994 Integrase catalytic domain profile.
101 264 InterPro IPR001584 Integrase, catalytic core
96 260 SUPERFAMILY SSF53098 Ribonuclease H-like
96 260 InterPro IPR012337 Ribonuclease H-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A377VVV9
AlphaFold — — full sequence — Viewing
ColabFold KP13_02534
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.416

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.3 0.178
2 2.91 0.093
3 1.15 0.009