Protein profile

KP13_02542

Hemin-binding periplasmic protein HmuT

Genome: KpKP13

Gene: AHE43005.1 hmuT Structure source: AlphaFold + ColabFold UniProt A0A0H3GWS0
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Amino acids 272
Annotations 0
Features 16
PDB binders 0
Druggability 0.117

Overview

Basic information about this protein and its source genome.

Accession
KP13_02542
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43005.1 hmuT
Status
annotated
Amino acids
272
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.04

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.117
Structure A0A0H3GWS0
Pocket Pocket 1
P2Rank 0.277
Structure A0A0H3GWS0
Pocket Pocket 1
ColabFold model
FPocket 0.251 · Pocket 2
P2Rank 0.48 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 75 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
11 139 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
21 272 ProSiteProfiles PS50983 Iron siderophore/cobalamin periplasmic-binding domain profile.
21 272 InterPro IPR002491 ABC transporter periplasmic binding domain
19 249 CDD cd01149 HutB
5 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
140 271 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
23 247 Pfam PF01497 Periplasmic binding protein
23 247 InterPro IPR002491 ABC transporter periplasmic binding domain
17 264 PANTHER PTHR30535 VITAMIN B12-BINDING PROTEIN
1 17 Phobius SIGNAL_PEPTIDE Signal peptide region
14 17 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 17 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
19 265 SUPERFAMILY SSF53807 Helical backbone metal receptor
18 272 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 17 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWS0
AlphaFold — — full sequence — Viewing
ColabFold KP13_02542
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.65 0.078