Protein profile

KP13_02543

Hemin transport protein HmuS

Genome: KpKP13

Gene: AHE43006.1 hmuS Structure source: AlphaFold + ColabFold UniProt A0A0H3GXE8
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Amino acids 345
Annotations 3
Features 11
PDB binders 0
Druggability 0.367

Overview

Basic information about this protein and its source genome.

Accession
KP13_02543
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43006.1 hmuS
Status
annotated
Amino acids
345
Structure source
AlphaFold + ColabFold
GO
GO:0006826 The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
93.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.367
Structure A0A0H3GXE8
Pocket Pocket 28
P2Rank 0.858
Structure A0A0H3GXE8
Pocket Pocket 1
ColabFold model
FPocket 0.561 · Pocket 22
P2Rank 0.869 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 85 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006826 The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
14 281 Gene3D G3DSA:3.40.1570.10 HemS/ChuS/ChuX like domains
9 339 SUPERFAMILY SSF144064 Heme iron utilization protein-like
34 158 Pfam PF05171 Haemin-degrading HemS.ChuX domain
34 158 InterPro IPR007845 Haemin-degrading HemS/ChuX domain
207 338 Pfam PF05171 Haemin-degrading HemS.ChuX domain
207 338 InterPro IPR007845 Haemin-degrading HemS/ChuX domain
10 158 CDD cd16830 HemS-like_N
184 338 CDD cd16831 HemS-like_C
319 337 MobiDBLite mobidb-lite consensus disorder prediction
87 334 Gene3D G3DSA:3.40.1570.10 HemS/ChuS/ChuX like domains
319 345 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXE8
AlphaFold — — full sequence — Viewing
ColabFold KP13_02543
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
28 0.367
21 0.325

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 18.99 0.833
2 5.93 0.291
3 5.58 0.268