Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: KP13_02556
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: chbA AHE43019.1
Status: annotated
Amino acids: 104
Structure source: AlphaFold + ColabFold

GO

GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0046872 Binding to a metal ion. GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 65.625
DEG E-value: 1.66e-38
Localization: Cytoplasmic
ColabFold pLDDT: 92.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.067

Structure A0A0H3GUD6

Pocket Pocket 7

P2Rank

Structure A0A0H3GUD6

Pocket No pockets

ColabFold model

FPocket 0.278 · Pocket 3

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 119 / 4744 genomes with a hit

Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
GO:0046872 Binding to a metal ion.
GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records

Show feature table

Start	End	DB	Term	Name
1	103	PIRSF	PIRSF000699	PTS_IILac_III
1	103	InterPro	IPR003188	Phosphotransferase system, lactose/cellobiose-type IIA subunit
2	99	PANTHER	PTHR34382	PTS SYSTEM N,N'-DIACETYLCHITOBIOSE-SPECIFIC EIIA COMPONENT
2	99	InterPro	IPR003188	Phosphotransferase system, lactose/cellobiose-type IIA subunit
6	98	Pfam	PF02255	PTS system, Lactose/Cellobiose specific IIA subunit
6	98	InterPro	IPR003188	Phosphotransferase system, lactose/cellobiose-type IIA subunit
3	97	CDD	cd00215	PTS_IIA_lac
3	97	InterPro	IPR003188	Phosphotransferase system, lactose/cellobiose-type IIA subunit
1	99	ProSiteProfiles	PS51095	PTS_EIIA type-3 domain profile.
1	99	InterPro	IPR003188	Phosphotransferase system, lactose/cellobiose-type IIA subunit
1	98	SUPERFAMILY	SSF46973	Enzyme IIa from lactose specific PTS, IIa-lac
1	98	InterPro	IPR036542	Phosphotransferase system, lactose/cellobiose-type IIA subunit superfamily
1	101	Gene3D	G3DSA:1.20.58.80	-

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GUD6	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_02556	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.278

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
PO3	2LRL	P69791	79.0 Da LogP -1.64 TPSA 63.2	✓ Ro5	✓ Clean	`[O-][P-](=O)[O-]`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

KP13_02556