Protein profile

KP13_02562

hypothetical protein

Genome: KpKP13

Gene: AHE43025.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWQ4
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Amino acids 730
Annotations 6
Features 26
PDB binders 0
Druggability 0.513

Overview

Basic information about this protein and its source genome.

Accession
KP13_02562
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43025.1
Status
annotated
Amino acids
730
Structure source
AlphaFold + ColabFold
EC
3.2.1.78
GO
GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005515 Binding to a protein. GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0016985 Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
92.97

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.513
Structure A0A0H3GWQ4
Pocket Pocket 4
P2Rank 0.895
Structure A0A0H3GWQ4
Pocket Pocket 1
ColabFold model
FPocket 0.19 · Pocket 10
P2Rank 0.902 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 12 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
  • GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond.
  • GO:0005515 Binding to a protein.
  • GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
  • GO:0016985 Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
427 497 CDD cd00063 FN3
427 497 InterPro IPR003961 Fibronectin type III
1 23 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
402 501 Gene3D G3DSA:2.60.40.10 Immunoglobulins
402 501 InterPro IPR013783 Immunoglobulin-like fold
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
30 395 Gene3D G3DSA:3.20.20.80 Glycosidases
624 726 SUPERFAMILY SSF49785 Galactose-binding domain-like
624 726 InterPro IPR008979 Galactose-binding-like domain superfamily
12 371 PANTHER PTHR31451 -
12 371 InterPro IPR045053 Mannan endo-1,4-beta-mannosidase-like
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
7 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
608 729 Pfam PF16990 Carbohydrate binding module (family 35)
608 729 InterPro IPR005084 Carbohydrate binding module family 6
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
612 729 Gene3D G3DSA:2.60.120.260 -
502 590 Gene3D G3DSA:2.60.40.10 Immunoglobulins
502 590 InterPro IPR013783 Immunoglobulin-like fold
19 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
31 355 SUPERFAMILY SSF51445 (Trans)glycosidases
31 355 InterPro IPR017853 Glycoside hydrolase superfamily
399 504 SUPERFAMILY SSF49265 Fibronectin type III
399 504 InterPro IPR036116 Fibronectin type III superfamily
24 730 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWQ4
AlphaFold — — full sequence — Viewing
ColabFold KP13_02562
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.513
1 0.212
11 0.022
33 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 29.31 0.895
2 1.92 0.033
3 1.89 0.032
4 1.56 0.02
5 1.08 0.006