Protein profile

KP13_02567

Hydrogenase isoenzymes formation protein hypC

Genome: KpKP13

Gene: hypC AHE43030.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWQ2
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Amino acids 90
Annotations 3
Features 20
PDB binders 0
Druggability 0.401

Overview

Basic information about this protein and its source genome.

Accession
KP13_02567
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
hypC AHE43030.1
Status
annotated
Amino acids
90
Structure source
AlphaFold + ColabFold
GO
GO:1902670 Binding to carbon dioxide. GO:0005506 Binding to an iron (Fe) ion. GO:0051604 Any process leading to the attainment of the full functional capacity of a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
55.422
DEG E-value
1.89e-22
Localization
Unknown
ColabFold pLDDT
84.27

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.401
Structure A0A0H3GWQ2
Pocket Pocket 2
P2Rank 0.015
Structure A0A0H3GWQ2
Pocket Pocket 1
ColabFold model
FPocket 0.82 · Pocket 1
P2Rank 0.006 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 94 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:1902670 Binding to carbon dioxide.
  • GO:0005506 Binding to an iron (Fe) ion.
  • GO:0051604 Any process leading to the attainment of the full functional capacity of a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
1 84 NCBIfam TIGR00074 HypC/HybG/HupF family hydrogenase formation chaperone
1 84 InterPro IPR001109 Hydrogenase expression/formation protein, HupF/HypC
60 90 Gene3D G3DSA:6.10.250.910 -
62 74 PRINTS PR00445 HupF/HypC hydrogenase expression/synthesis family signature
62 74 InterPro IPR001109 Hydrogenase expression/formation protein, HupF/HypC
2 9 PRINTS PR00445 HupF/HypC hydrogenase expression/synthesis family signature
2 9 InterPro IPR001109 Hydrogenase expression/formation protein, HupF/HypC
17 33 PRINTS PR00445 HupF/HypC hydrogenase expression/synthesis family signature
17 33 InterPro IPR001109 Hydrogenase expression/formation protein, HupF/HypC
44 60 PRINTS PR00445 HupF/HypC hydrogenase expression/synthesis family signature
44 60 InterPro IPR001109 Hydrogenase expression/formation protein, HupF/HypC
1 79 PANTHER PTHR35177 HYDROGENASE MATURATION FACTOR HYBG
1 79 InterPro IPR001109 Hydrogenase expression/formation protein, HupF/HypC
1 86 SUPERFAMILY SSF159127 HupF/HypC-like
1 71 Pfam PF01455 HupF/HypC family
1 71 InterPro IPR001109 Hydrogenase expression/formation protein, HupF/HypC
1 59 Gene3D G3DSA:2.30.30.140 -
1 79 FunFam G3DSA:2.30.30.140:FF:000022 Hydrogenase assembly chaperone HybG
1 9 ProSitePatterns PS01097 Hydrogenases expression/synthesis hupF/hypC family signature.
1 9 InterPro IPR019812 Hydrogenase assembly chaperone, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWQ2
AlphaFold — — full sequence — Viewing
ColabFold KP13_02567
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.401