Protein profile

KP13_02571

putative hydrogenase nickel incorporation protein hypA

Genome: KpKP13

Gene: AHE43032.1 hypA Structure source: AlphaFold + ColabFold UniProt A0A0H3H1Y0
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Amino acids 114
Annotations 4
Features 11
PDB binders 0
Druggability 0.315

Overview

Basic information about this protein and its source genome.

Accession
KP13_02571
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43032.1 hypA
Status
annotated
Amino acids
114
Structure source
AlphaFold + ColabFold
GO
GO:0016151 Binding to a nickel (Ni) cation. GO:0051604 Any process leading to the attainment of the full functional capacity of a protein. GO:0016530 Binding to and delivering metal ions to a target protein. GO:0008270 Binding to a zinc ion (Zn).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.65

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.315
Structure A0A0H3H1Y0
Pocket Pocket 1
P2Rank
Structure A0A0H3H1Y0
Pocket No pockets
ColabFold model
FPocket 0.241 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 87 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016151 Binding to a nickel (Ni) cation.
  • GO:0051604 Any process leading to the attainment of the full functional capacity of a protein.
  • GO:0016530 Binding to and delivering metal ions to a target protein.
  • GO:0008270 Binding to a zinc ion (Zn).

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
34 76 ProSitePatterns PS01249 Hydrogenases expression/synthesis hypA family signature.
34 76 InterPro IPR020538 Hydrogenase nickel incorporation protein HypA/HybF, conserved site
1 114 PIRSF PIRSF004761 Hydrgn_mat_HypA
1 114 InterPro IPR000688 Hydrogenase maturation factor HypA/HybF
1 114 Gene3D G3DSA:3.30.2320.80 -
1 114 Hamap MF_00213 Hydrogenase maturation factor HypA [hypA].
1 114 PANTHER PTHR34535 HYDROGENASE MATURATION FACTOR HYPA
1 114 FunFam G3DSA:3.30.2320.80:FF:000001 Hydrogenase maturation factor HypA
1 112 Pfam PF01155 Hydrogenase/urease nickel incorporation, metallochaperone, hypA
1 112 InterPro IPR000688 Hydrogenase maturation factor HypA/HybF
1 114 NCBIfam TIGR00100 hydrogenase maturation nickel metallochaperone HypA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H1Y0
AlphaFold — — full sequence — Viewing
ColabFold KP13_02571
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.315