Protein profile

KP13_02580

Hydrogenase 3 maturation protease

Genome: KpKP13

Gene: AHE43041.1 hycI Structure source: AlphaFold + ColabFold UniProt A0A0H3GS61
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Amino acids 156
Annotations 4
Features 24
PDB binders 0
Druggability 0.193

Overview

Basic information about this protein and its source genome.

Accession
KP13_02580
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43041.1 hycI
Status
annotated
Amino acids
156
Structure source
AlphaFold + ColabFold
GO
GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0008047 A molecular function regulator that increases a catalytic activity. GO:0004175 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. GO:0016485 Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
85.897
DEG E-value
1.3e-98
Localization
Unknown
ColabFold pLDDT
88.64

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.193
Structure A0A0H3GS61
Pocket Pocket 12
P2Rank 0.122
Structure A0A0H3GS61
Pocket Pocket 1
ColabFold model
FPocket 0.231 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 115 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
  • GO:0008047 A molecular function regulator that increases a catalytic activity.
  • GO:0004175 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
  • GO:0016485 Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
29 140 Pfam PF01750 Hydrogenase maturation protease
29 140 InterPro IPR000671 Peptidase A31 family
2 151 SUPERFAMILY SSF53163 HybD-like
2 151 InterPro IPR023430 Peptidase HybD-like domain superfamily
3 15 PRINTS PR00446 Hydrogen uptake protein signature
3 15 InterPro IPR000671 Peptidase A31 family
67 83 PRINTS PR00446 Hydrogen uptake protein signature
67 83 InterPro IPR000671 Peptidase A31 family
15 26 PRINTS PR00446 Hydrogen uptake protein signature
15 26 InterPro IPR000671 Peptidase A31 family
56 66 PRINTS PR00446 Hydrogen uptake protein signature
56 66 InterPro IPR000671 Peptidase A31 family
33 50 PRINTS PR00446 Hydrogen uptake protein signature
33 50 InterPro IPR000671 Peptidase A31 family
1 156 Gene3D G3DSA:3.40.50.1450 -
1 156 InterPro IPR023430 Peptidase HybD-like domain superfamily
3 146 NCBIfam TIGR00142 hydrogenase maturation peptidase HycI
3 146 InterPro IPR004420 Peptidase A31, hydrogenase maturation protease HycI
4 139 CDD cd06067 H2MP_MemB-H2evol
4 139 InterPro IPR004420 Peptidase A31, hydrogenase maturation protease HycI
2 148 PANTHER PTHR30302 HYDROGENASE 1 MATURATION PROTEASE
2 148 InterPro IPR000671 Peptidase A31 family
5 140 NCBIfam TIGR00072 hydrogenase maturation protease
5 140 InterPro IPR000671 Peptidase A31 family

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GS61
AlphaFold — — full sequence — Viewing
ColabFold KP13_02580
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.06 0.046