Protein profile

KP13_31567

Glucitol/sorbitol permease IIC component

Genome: KpKP13

Gene: AHE43058.1 srlA Structure source: AlphaFold + ColabFold UniProt A0A0H3GX71
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Amino acids 187
Annotations 2
Features 20
PDB binders 0
Druggability 0.766

Overview

Basic information about this protein and its source genome.

Accession
KP13_31567
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43058.1 srlA
Status
annotated
Amino acids
187
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.51

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.766
Structure A0A0H3GX71
Pocket Pocket 12
P2Rank 0.712
Structure A0A0H3GX71
Pocket Pocket 1
ColabFold model
FPocket 0.525 · Pocket 4
P2Rank 0.26 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 148 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
134 156 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 21 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 182 PIRSF PIRSF038321 PTS_glc_srb_IIC
2 182 InterPro IPR004699 Phosphotransferase system, enzyme II sorbitol-specific factor
1 187 ProSiteProfiles PS51107 PTS_EIIC type-5 domain profile.
1 187 InterPro IPR004699 Phosphotransferase system, enzyme II sorbitol-specific factor
26 48 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
22 48 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
49 68 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
122 149 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 181 NCBIfam TIGR00821 glucitol/sorbitol-specific PTS transporter subunit IIC
1 181 InterPro IPR004699 Phosphotransferase system, enzyme II sorbitol-specific factor
150 187 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
69 91 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
2 176 PANTHER PTHR40399 PTS SYSTEM GLUCITOL/SORBITOL-SPECIFIC EIIC COMPONENT
2 176 InterPro IPR004699 Phosphotransferase system, enzyme II sorbitol-specific factor
92 121 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
68 90 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 170 Pfam PF03608 PTS system enzyme II sorbitol-specific factor
6 170 InterPro IPR004699 Phosphotransferase system, enzyme II sorbitol-specific factor

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GX71
AlphaFold — — full sequence — Viewing
ColabFold KP13_31567
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.766
1 0.512
13 0.296

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.93 0.739
2 1.49 0.021