Protein profile

KP13_02606

Carbon storage regulator

Genome: KpKP13

Gene: AHE43064.1 csrA Structure source: AlphaFold + ColabFold UniProt A6TCV8
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Amino acids 61
Annotations 3
Features 12
PDB binders 0
Druggability 0.103

Overview

Basic information about this protein and its source genome.

Accession
KP13_02606
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43064.1 csrA
Status
annotated
Amino acids
61
Structure source
AlphaFold + ColabFold
GO
GO:0006109 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. GO:0006402 The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. GO:0003723 Binding to an RNA molecule or a portion thereof.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
100.0
DEG E-value
3.61e-39
Localization
Unknown
ColabFold pLDDT
88.48

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.103
Structure A6TCV8
Pocket Pocket 1
P2Rank
Structure A6TCV8
Pocket No pockets
ColabFold model
FPocket 0.349 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 243 / 4744 genomes with a hit
Normalized 0.051

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006109 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.
  • GO:0006402 The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
  • GO:0003723 Binding to an RNA molecule or a portion thereof.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 52 Pfam PF02599 Global regulator protein family
1 52 InterPro IPR003751 Translational regulator CsrA
1 61 Gene3D G3DSA:2.60.40.4380 Translational regulator CsrA
1 61 InterPro IPR036107 Carbon storage regulator superfamily
1 54 SUPERFAMILY SSF117130 CsrA-like
1 54 InterPro IPR036107 Carbon storage regulator superfamily
1 60 PANTHER PTHR34984 CARBON STORAGE REGULATOR
1 60 InterPro IPR003751 Translational regulator CsrA
1 60 Hamap MF_00167 Translational regulator CsrA [csrA].
1 57 NCBIfam TIGR00202 carbon storage regulator CsrA
1 57 InterPro IPR003751 Translational regulator CsrA
1 60 FunFam G3DSA:2.60.40.4380:FF:000001 Translational regulator CsrA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A6TCV8
AlphaFold — — full sequence — Viewing
ColabFold KP13_02606
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer