Protein profile

KP13_16529

Transport-associated and nodulation domain-containing protein

Genome: KpKP13

Gene: ANJ86587.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GS41
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Amino acids 104
Annotations 1
Features 16
PDB binders 0
Druggability 0.829

Overview

Basic information about this protein and its source genome.

Accession
KP13_16529
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ANJ86587.1
Status
annotated
Amino acids
104
Structure source
AlphaFold + ColabFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
82.56

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.829
Structure A0A0H3GS41
Pocket Pocket 3
P2Rank
Structure A0A0H3GS41
Pocket No pockets
ColabFold model
FPocket 0.387 · Pocket 2
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 61 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
40 104 Gene3D G3DSA:3.30.1340.30 -
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 21 SignalP_EUK SignalP-noTM SignalP-noTM
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
37 104 ProSiteProfiles PS50914 BON domain profile.
37 104 InterPro IPR007055 BON domain
6 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 26 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
27 104 PANTHER PTHR34606 BON DOMAIN-CONTAINING PROTEIN
37 104 Pfam PF04972 BON domain
39 104 FunFam G3DSA:3.30.1340.30:FF:000001 Molecular chaperone OsmY
22 104 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 23 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
42 104 SMART SM00749 bon
42 104 InterPro IPR014004 Transport-associated and nodulation domain, bacteria

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GS41
AlphaFold — — full sequence — Viewing
ColabFold KP13_16529
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.829
2 0.796
7 0.369