Protein profile

KP13_02610

Inner membrane protein

Genome: KpKP13

Gene: AHE43066.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GU95
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Amino acids 142
Annotations 1
Features 18
PDB binders 0
Druggability 0.546

Overview

Basic information about this protein and its source genome.

Accession
KP13_02610
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43066.1
Status
annotated
Amino acids
142
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.546
Structure A0A0H3GU95
Pocket Pocket 7
P2Rank
Structure A0A0H3GU95
Pocket No pockets
ColabFold model
FPocket 0.861 · Pocket 1
P2Rank 0.022 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 87 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
4 12 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
113 135 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 141 PANTHER PTHR42709 ALKALINE PHOSPHATASE LIKE PROTEIN
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
13 17 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
114 135 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
42 64 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
109 113 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
86 108 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
41 65 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
15 37 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
18 40 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
25 131 Pfam PF09335 SNARE associated Golgi protein
25 131 InterPro IPR032816 SNARE associated Golgi protein
66 85 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 17 Phobius SIGNAL_PEPTIDE Signal peptide region
84 106 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
136 142 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU95
AlphaFold — — full sequence — Viewing
ColabFold KP13_02610
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.546
3 0.388
1 0.189
2 0.062