Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: KP13_31576
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE43071.1
Status: annotated
Amino acids: 390
Structure source: AlphaFold + ColabFold

GO

GO:1990961 A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. GO:0042910 Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015721 The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 50.535
DEG E-value: 7.37e-125
Localization: CytoplasmicMembrane
ColabFold pLDDT: 91.78

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.085

Structure A0A0H3GWJ4

Pocket Pocket 2

P2Rank 0.004

Structure A0A0H3GWJ4

Pocket Pocket 1

ColabFold model

FPocket 0.132 · Pocket 16

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 124 / 4744 genomes with a hit

Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:1990961 A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
GO:0042910 Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0015721 The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records

Show feature table

Start	End	DB	Term	Name
56	113	SUPERFAMILY	SSF111369	HlyD-like secretion proteins
61	124	Gene3D	G3DSA:2.40.50.100	-
23	44	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
36	345	Pfam	PF00529	Cation efflux system protein CusB domain 1
36	345	InterPro	IPR043602	Cation efflux system protein CusB, domain 1
160	180	Coils	Coil	Coil
1	361	PANTHER	PTHR30386	MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP
194	270	SUPERFAMILY	SSF111369	HlyD-like secretion proteins
234	354	Gene3D	G3DSA:2.40.30.170	-
23	45	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
232	354	FunFam	G3DSA:2.40.30.170:FF:000003	Multidrug resistance protein A
170	289	Pfam	PF16576	Barrel-sandwich domain of CusB or HlyD membrane-fusion
170	289	InterPro	IPR032317	RND efflux pump, membrane fusion protein, barrel-sandwich domain
20	345	NCBIfam	TIGR00998	EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit
20	345	InterPro	IPR005694	Membrane fusion proteins, proteobacteria
45	390	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
122	142	Coils	Coil	Coil
1	22	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0H3GWJ4 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GWJ4	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_31576	ColabFold	—	—	full sequence	—	Loaded

KP13_31576