Protein profile

KP13_04111

Glutaredoxin-like protein nrdH

Genome: KpKP13

Gene: AHE43079.1 nrdH Structure source: AlphaFold + ColabFold UniProt A6TCT9
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Amino acids 61
Annotations 0
Features 4
PDB binders 0
Druggability 0.497

Overview

Basic information about this protein and its source genome.

Accession
KP13_04111
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43079.1 nrdH
Status
annotated
Amino acids
61
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
73.77
DEG E-value
1.1199999999999999e-28
Localization
Unknown
ColabFold pLDDT
87.19

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.497
Structure A6TCT9
Pocket Pocket 2
P2Rank 0.008
Structure A6TCT9
Pocket Pocket 1
ColabFold model
FPocket 0.291 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 67 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

4 records
Show feature table
Start End DB Term Name
1 52 CDD cd02976 NrdH
1 61 Gene3D G3DSA:3.40.30.10 Glutaredoxin
2 52 SUPERFAMILY SSF52833 Thioredoxin-like
2 52 InterPro IPR036249 Thioredoxin-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A6TCT9
AlphaFold — — full sequence — Viewing
ColabFold KP13_04111
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.497
1 0.014

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.16 0.008