Protein profile

KP13_04104

DNA-binding protein stpA

Genome: KpKP13

Gene: AHE43087.1 stpA Structure source: AlphaFold + ColabFold UniProt A0A0H3GU68
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Amino acids 139
Annotations 11
Features 16
PDB binders 0
Druggability 0.568

Overview

Basic information about this protein and its source genome.

Accession
KP13_04104
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43087.1 stpA
Status
annotated
Amino acids
139
Structure source
AlphaFold + ColabFold
GO
GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0046983 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0009295 The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
65.926
DEG E-value
7.24e-58
Localization
Cytoplasmic
ColabFold pLDDT
86.91

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.568
Structure A0A0H3GU68
Pocket Pocket 8
P2Rank
Structure A0A0H3GU68
Pocket No pockets
ColabFold model
FPocket 0.605 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 54 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

11 GO

Gene Ontology (GO)

11
  • GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0046983 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0009295 The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined.
  • GO:0032993 A macromolecular complex containing both protein and DNA molecules.
  • GO:0003681 Binding to DNA in a bent conformation.
  • GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
  • GO:0003680 Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
97 139 SUPERFAMILY SSF81273 H-NS histone-like proteins
44 133 Pfam PF00816 H-NS histone family
44 133 InterPro IPR001801 Histone-like protein H-NS
5 87 Gene3D G3DSA:1.10.287.1050 -
5 87 InterPro IPR027454 Histone-like protein H-NS, N-terminal
28 139 PANTHER PTHR38097 -
79 122 MobiDBLite mobidb-lite consensus disorder prediction
8 63 SUPERFAMILY SSF81273 H-NS histone-like proteins
96 139 Gene3D G3DSA:4.10.430.10 -
96 139 InterPro IPR037150 Histone-like protein H-NS, C-terminal domain superfamily
92 139 SMART SM00528 hnsneu2
92 139 InterPro IPR027444 Histone-like protein H-NS, C-terminal domain
29 59 Coils Coil Coil
7 139 PIRSF PIRSF002096 HnS
7 139 InterPro IPR001801 Histone-like protein H-NS
96 139 FunFam G3DSA:4.10.430.10:FF:000001 DNA-binding protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU68
AlphaFold — — full sequence — Viewing
ColabFold KP13_04104
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.376
7 0.192
2 0.037
5 0.011