Protein profile

KP13_04100

Inner membrane protein

Genome: KpKP13

Gene: AHE43091.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GS20
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Amino acids 181
Annotations 1
Features 21
PDB binders 0
Druggability 0.66

Overview

Basic information about this protein and its source genome.

Accession
KP13_04100
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43091.1
Status
annotated
Amino acids
181
Structure source
AlphaFold + ColabFold
GO
GO:0004792 Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
67.241
DEG E-value
9.56e-80
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.93

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.66
Structure A0A0H3GS20
Pocket Pocket 3
P2Rank 0.093
Structure A0A0H3GS20
Pocket Pocket 1
ColabFold model
FPocket 0.581 · Pocket 3
P2Rank 0.091 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 57 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0004792 Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
136 140 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 154 SUPERFAMILY SSF52821 Rhodanese/Cell cycle control phosphatase
2 154 InterPro IPR036873 Rhodanese-like domain superfamily
109 174 Gene3D G3DSA:6.10.140.1340 -
15 105 ProSiteProfiles PS50206 Rhodanese domain profile.
15 105 InterPro IPR001763 Rhodanese-like domain
7 119 PANTHER PTHR44086 THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED
145 167 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
117 135 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 116 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
115 171 Pfam PF11127 Protein of unknown function (DUF2892)
115 171 InterPro IPR021309 Inner membrane protein YgaP-like, transmembrane domain
4 108 Gene3D G3DSA:3.40.250.10 -
4 108 InterPro IPR036873 Rhodanese-like domain superfamily
7 99 Pfam PF00581 Rhodanese-like domain
7 99 InterPro IPR001763 Rhodanese-like domain
141 165 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
119 141 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
166 181 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
5 102 SMART SM00450 rhod_4
5 102 InterPro IPR001763 Rhodanese-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GS20
AlphaFold — — full sequence — Viewing
ColabFold KP13_04100
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.66
14 0.211

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.18 0.109