Protein profile

KP13_05178

Outer membrane usher protein

Genome: KpKP13

Gene: AHE43103.1 Structure source: AlphaFold + ColabFold UniProt A0A6A8ECD3
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Amino acids 859
Annotations 5
Features 24
PDB binders 0
Druggability 0.783

Overview

Basic information about this protein and its source genome.

Accession
KP13_05178
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43103.1
Status
annotated
Amino acids
859
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
84.91

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.783
Structure A0A6A8ECD3
Pocket Pocket 6
P2Rank 0.417
Structure A0A6A8ECD3
Pocket Pocket 1
ColabFold model
FPocket 0.879 · Pocket 73
P2Rank 0.446 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 19 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005515 Binding to a protein.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
  • GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
767 858 Gene3D G3DSA:2.60.40.2070 -
767 858 InterPro IPR043142 PapC-like, C-terminal domain superfamily
1 19 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
42 859 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
285 374 Gene3D G3DSA:2.60.40.3110 -
216 760 Pfam PF00577 Outer membrane usher protein
216 760 InterPro IPR000015 Outer membrane usher protein
770 839 Pfam PF13953 PapC C-terminal domain
770 839 InterPro IPR025949 PapC-like, C-terminal domain
79 191 SUPERFAMILY SSF141729 FimD N-terminal domain-like
79 191 InterPro IPR037224 PapC, N-terminal domain superfamily
327 337 ProSitePatterns PS01151 Fimbrial biogenesis outer membrane usher protein signature.
327 337 InterPro IPR018030 Fimbrial membrane usher, conserved site
32 848 PANTHER PTHR30451 OUTER MEMBRANE USHER PROTEIN
32 848 InterPro IPR000015 Outer membrane usher protein
676 766 Gene3D G3DSA:2.60.40.2610 Outer membrane usher protein FimD, plug domain
676 766 InterPro IPR042186 Outer membrane usher protein FimD, plug domain
676 766 FunFam G3DSA:2.60.40.2610:FF:000001 Outer membrane fimbrial usher protein
71 188 Gene3D G3DSA:3.10.20.410 -
71 188 InterPro IPR037224 PapC, N-terminal domain superfamily
20 41 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
285 374 FunFam G3DSA:2.60.40.3110:FF:000001 Putative fimbrial outer membrane usher
54 199 Pfam PF13954 PapC N-terminal domain
54 199 InterPro IPR025885 PapC, N-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6A8ECD3
AlphaFold — — full sequence — Viewing
ColabFold KP13_05178
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.783
10 0.709
46 0.382
48 0.381

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.76 0.28
2 2.78 0.085
3 1.27 0.013
4 1.26 0.013
5 1.26 0.013