Protein profile

KP13_02458

putative fimbrial biogenesis outer membrane usher protein

Genome: KpKP13

Gene: AHE43106.1 Structure source: AlphaFold + ColabFold UniProt A0A6A8ECN8
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Amino acids 845
Annotations 5
Features 25
PDB binders 0
Druggability 0.918

Overview

Basic information about this protein and its source genome.

Accession
KP13_02458
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43106.1
Status
annotated
Amino acids
845
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
86.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.918
Structure A0A6A8ECN8
Pocket Pocket 7
P2Rank 0.24
Structure A0A6A8ECN8
Pocket Pocket 1
ColabFold model
FPocket 0.132 · Pocket 7
P2Rank 0.338 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005515 Binding to a protein.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
  • GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
40 151 Gene3D G3DSA:3.10.20.410 -
40 151 InterPro IPR037224 PapC, N-terminal domain superfamily
248 336 Gene3D G3DSA:2.60.40.3110 -
6 839 PANTHER PTHR30451 OUTER MEMBRANE USHER PROTEIN
6 839 InterPro IPR000015 Outer membrane usher protein
24 845 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
247 336 FunFam G3DSA:2.60.40.3110:FF:000001 Putative fimbrial outer membrane usher
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
755 842 Gene3D G3DSA:2.60.40.2070 -
755 842 InterPro IPR043142 PapC-like, C-terminal domain superfamily
20 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
9 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
664 754 Gene3D G3DSA:2.60.40.2610 Outer membrane usher protein FimD, plug domain
664 754 InterPro IPR042186 Outer membrane usher protein FimD, plug domain
758 818 Pfam PF13953 PapC C-terminal domain
758 818 InterPro IPR025949 PapC-like, C-terminal domain
48 154 SUPERFAMILY SSF141729 FimD N-terminal domain-like
48 154 InterPro IPR037224 PapC, N-terminal domain superfamily
177 749 Pfam PF00577 Outer membrane usher protein
177 749 InterPro IPR000015 Outer membrane usher protein
39 162 Pfam PF13954 PapC N-terminal domain
39 162 InterPro IPR025885 PapC, N-terminal domain
289 299 ProSitePatterns PS01151 Fimbrial biogenesis outer membrane usher protein signature.
289 299 InterPro IPR018030 Fimbrial membrane usher, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6A8ECN8
AlphaFold — — full sequence — Viewing
ColabFold KP13_02458
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.918
41 0.422
9 0.291

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.31 0.116
2 2.45 0.067
3 2.21 0.054
4 2.04 0.045
5 1.96 0.041