Protein profile

KP13_02440

Efflux pump OqxA

Genome: KpKP13

Gene: AHE43123.1 oqxA Structure source: AlphaFold + ColabFold UniProt A0A1Y0PW27
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Amino acids 391
Annotations 5
Features 20
PDB binders 0
Druggability 0.45

Overview

Basic information about this protein and its source genome.

Accession
KP13_02440
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43123.1 oqxA
Status
annotated
Amino acids
391
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.77

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.45
Structure A0A1Y0PW27
Pocket Pocket 9
P2Rank 0.409
Structure A0A1Y0PW27
Pocket Pocket 1
ColabFold model
FPocket 0.828 · Pocket 1
P2Rank 0.332 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 44 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
66 211 Gene3D G3DSA:2.40.50.100 -
67 297 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
67 297 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
28 391 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
24 27 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
288 380 FunFam G3DSA:2.40.420.20:FF:000001 Efflux RND transporter periplasmic adaptor subunit
288 380 Gene3D G3DSA:2.40.420.20 -
152 172 Coils Coil Coil
1 11 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
101 174 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
1 27 SignalP_EUK SignalP-noTM SignalP-noTM
1 27 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
42 378 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
42 378 InterPro IPR006143 RND efflux pump, membrane fusion protein
107 127 Coils Coil Coil
60 287 Gene3D G3DSA:2.40.30.170 -
57 302 SUPERFAMILY SSF111369 HlyD-like secretion proteins
10 387 PANTHER PTHR30158 ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER
12 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 27 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1Y0PW27
AlphaFold — — full sequence — Viewing
ColabFold KP13_02440
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.45
6 0.27

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.81 0.348