Protein profile

KP13_02438

Flavin reductase domain-containing protein

Genome: KpKP13

Gene: AHE43124.1 Structure source: AlphaFold + ColabFold UniProt A0A2X3F3G2
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Amino acids 241
Annotations 2
Features 8
PDB binders 0
Druggability 0.217

Overview

Basic information about this protein and its source genome.

Accession
KP13_02438
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43124.1
Status
annotated
Amino acids
241
Structure source
AlphaFold + ColabFold
GO
GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016646 Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
85.63

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.217
Structure A0A2X3F3G2
Pocket Pocket 11
P2Rank 0.111
Structure A0A2X3F3G2
Pocket Pocket 1
ColabFold model
FPocket 0.521 · Pocket 6
P2Rank 0.387 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 11 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
  • GO:0016646 Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
65 202 SMART SM00903 Flavin_Reduct_2
65 202 InterPro IPR002563 Flavin reductase like domain
58 231 PANTHER PTHR43567 FLAVOREDOXIN-RELATED-RELATED
98 199 Pfam PF01613 Flavin reductase like domain
98 199 InterPro IPR002563 Flavin reductase like domain
52 229 SUPERFAMILY SSF50475 FMN-binding split barrel
44 233 Gene3D G3DSA:2.30.110.10 -
44 233 InterPro IPR012349 FMN-binding split barrel

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A2X3F3G2
AlphaFold — — full sequence — Viewing
ColabFold KP13_02438
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.217

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.19 0.052