Protein profile

KP13_02435

SsrA-binding protein

Genome: KpKP13

Gene: smpB AHE43129.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H1S8
Export view
Amino acids 160
Annotations 4
Features 17
PDB binders 0
Druggability 0.711

Overview

Basic information about this protein and its source genome.

Accession
KP13_02435
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
smpB AHE43129.1
Status
annotated
Amino acids
160
Structure source
AlphaFold + ColabFold
GO
GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0070929 A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes. GO:0070930 A protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
75.625
DEG E-value
6.5e-88
Localization
Unknown
ColabFold pLDDT
88.82

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.711
Structure A0A0H3H1S8
Pocket Pocket 2
P2Rank
Structure A0A0H3H1S8
Pocket No pockets
ColabFold model
FPocket 0.292 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 212 / 4744 genomes with a hit
Normalized 0.045

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0070929 A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes.
  • GO:0070930 A protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
1 160 Hamap MF_00023 SsrA-binding protein [smpB].
1 160 InterPro IPR000037 SsrA-binding protein
14 156 NCBIfam TIGR00086 SsrA-binding protein
14 156 InterPro IPR000037 SsrA-binding protein
7 135 FunFam G3DSA:2.40.280.10:FF:000001 SsrA-binding protein
32 44 ProSitePatterns PS01317 SsrA-binding protein.
32 44 InterPro IPR020081 SsrA-binding protein, conserved site
14 157 Pfam PF01668 SmpB protein
14 157 InterPro IPR000037 SsrA-binding protein
8 138 SUPERFAMILY SSF74982 Small protein B (SmpB)
8 138 InterPro IPR023620 Small protein B
17 133 CDD cd09294 SmpB
17 133 InterPro IPR000037 SsrA-binding protein
7 135 Gene3D G3DSA:2.40.280.10 -
7 135 InterPro IPR023620 Small protein B
5 157 PANTHER PTHR30308 TMRNA-BINDING COMPONENT OF TRANS-TRANSLATION TAGGING COMPLEX
5 157 InterPro IPR000037 SsrA-binding protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H1S8
AlphaFold — — full sequence — Viewing
ColabFold KP13_02435
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.711