Protein profile

KP13_02434

START-like domain-containing protein

Genome: KpKP13

Gene: AHE43130.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GU57
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Amino acids 158
Annotations 3
Features 15
PDB binders 0
Druggability 0.843

Overview

Basic information about this protein and its source genome.

Accession
KP13_02434
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43130.1
Status
annotated
Amino acids
158
Structure source
AlphaFold + ColabFold
GO
GO:0045333 The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. GO:0048039 Binding to ubiquinone, a quinone derivative with a tail of isoprene units.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
28.148
Human E-value
4.71e-12
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
85.987
DEG E-value
2.82e-98
Localization
Unknown
ColabFold pLDDT
93.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.843
Structure A0A0H3GU57
Pocket Pocket 1
P2Rank 0.784
Structure A0A0H3GU57
Pocket Pocket 1
ColabFold model
FPocket 0.61 · Pocket 1
P2Rank 0.765 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 123 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0045333 The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).
  • GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
  • GO:0048039 Binding to ubiquinone, a quinone derivative with a tail of isoprene units.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
2 10 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 15 Phobius SIGNAL_PEPTIDE Signal peptide region
15 157 Gene3D G3DSA:3.30.530.20 -
15 157 InterPro IPR023393 START-like domain superfamily
18 157 PANTHER PTHR12901 SPERM PROTEIN HOMOLOG
18 157 InterPro IPR044996 Coenzyme Q-binding protein COQ10-like
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
23 148 Pfam PF03364 Polyketide cyclase / dehydrase and lipid transport
23 148 InterPro IPR005031 Coenzyme Q-binding protein COQ10, START domain
14 156 SUPERFAMILY SSF55961 Bet v1-like
17 154 CDD cd07813 COQ10p_like
17 154 InterPro IPR044996 Coenzyme Q-binding protein COQ10-like
11 15 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
15 157 FunFam G3DSA:3.30.530.20:FF:000005 Type II toxin-antitoxin system toxin RatA
16 158 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU57
AlphaFold — — full sequence — Viewing
ColabFold KP13_02434
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.843

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.95 0.811