Protein profile

KP13_31627

SMP-30/Gluconolaconase/LRE domain-containing protein

Genome: KpKP13

Gene: AHE43149.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H1N0
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Amino acids 290
Annotations 3
Features 18
PDB binders 0
Druggability 0.931

Overview

Basic information about this protein and its source genome.

Accession
KP13_31627
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43149.1
Status
annotated
Amino acids
290
Structure source
AlphaFold + ColabFold
GO
GO:0005509 Binding to a calcium ion (Ca2+). GO:0004341 Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. GO:0019853 The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
30.403
Human E-value
1.91e-31
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.22

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.931
Structure A0A0H3H1N0
Pocket Pocket 1
P2Rank 0.666
Structure A0A0H3H1N0
Pocket Pocket 1
ColabFold model
FPocket 0.701 · Pocket 1
P2Rank 0.651 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 53 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005509 Binding to a calcium ion (Ca2+).
  • GO:0004341 Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate.
  • GO:0019853 The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
15 32 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature
15 32 InterPro IPR005511 Senescence marker protein-30 (SMP-30)
194 211 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature
194 211 InterPro IPR005511 Senescence marker protein-30 (SMP-30)
132 154 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature
132 154 InterPro IPR005511 Senescence marker protein-30 (SMP-30)
91 112 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature
91 112 InterPro IPR005511 Senescence marker protein-30 (SMP-30)
155 175 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature
155 175 InterPro IPR005511 Senescence marker protein-30 (SMP-30)
236 254 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature
236 254 InterPro IPR005511 Senescence marker protein-30 (SMP-30)
14 254 Pfam PF08450 SMP-30/Gluconolactonase/LRE-like region
14 254 InterPro IPR013658 SMP-30/Gluconolactonase/LRE-like region
4 288 Gene3D G3DSA:2.120.10.30 -
4 288 InterPro IPR011042 Six-bladed beta-propeller, TolB-like
9 288 PANTHER PTHR10907 REGUCALCIN
4 285 SUPERFAMILY SSF63829 Calcium-dependent phosphotriesterase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H1N0
AlphaFold — — full sequence — Viewing
ColabFold KP13_31627
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.931

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.11 0.596
2 1.4 0.017